Activity in vitro of hydrogen peroxide vapour against Clostridium difficile spores

F. Barbut^*, S. Yezli, J.A. Otter
^*Hôpital Saint-Antoine, France
Journal of Hospital Infection (2012) 80, 85-87
クロストリジウム・ディフィシル（Clostridium difficile）芽胞は感染患者から多量に排出され、乾燥処理や消毒薬に抵抗性を示す。複数株の C. difficile 芽胞に対する過酸化水素蒸気の in vitro 活性を、芽胞・担体試験（spore-carrier test）を用いて調べた。平均 4.7 ～ 6.9 log₁₀ の芽胞をポリ塩化ビニルまたはラミネート製の担体に接種して乾燥させ、次いで過酸化水素蒸気により汚染除去を行った。C. difficile 株や表面の材質にかかわらず、C. difficile は曝露された担体から完全に除去された。過酸化水素蒸気は、病院環境からの C. difficile 芽胞の除去法の候補となり得る。

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